Current medical imaging techniques for tracking therapy response are limited by resolution, biomarker scope, or depth of penetration. This research introduces a miniaturized, implantable fluorescence imager designed for real-time, dynamic molecular imaging within the body. The device successfully demonstrated tracking of a targeted therapy's distribution in a mouse model, paving the way for a continuous, internal biopsy system to assess treatment effectiveness.
Lensless imaging enables exceptionally compact fluorescence sensors. This paper analyzes and optimizes a technique using a fiber optic plate to improve image resolution and angle-insensitivity in lensless systems for multicolor fluorescence imaging.
A study presents a wireless, multicolor fluorescence image sensor implant for real-time monitoring in cancer therapy. The sensor, 2.5x5mm^2 in size, operates wirelessly via ultrasound and captures images with <125 micron resolution. It has been tested for imaging effector and suppressor immune cells in ex vivo mouse tumor samples. The device shows promise for rapid insight into therapeutic response and resistance, guiding personalized medicine.
