klotz: hydrogen bonding* + biochemistry*

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  1. This article explains how hydrophobic effects aren't simply about 'attraction' but are primarily driven by entropy. Water's strong hydrogen bonding network is disrupted when nonpolar molecules are introduced, decreasing entropy. The system minimizes this by reducing the surface area of contact between water and the nonpolar substance, leading to aggregation – the hydrophobic effect. It also clarifies the role of enthalpy, which is often less significant than entropy in this process.

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