(+)-JRT, a de novo synthesized LSD analogue (two-atom transposition), retains potent neuroplasticity-promoting effects while markedly reducing hallucinogenic liability. It offers a path toward treating depression, addiction, and cognition deficits in patients (e.g., SCZ, psychosis family history) for whom classical psychedelics are contraindicated.
- **Mechanism:** promotes cortical spinogenesis / dendritic growth (same pathway as LSD)
- **Selectivity:** improved receptor pharmacology; does *not* amplify psychosis-associated behavioral or gene-expression signatures
- **Behavioral readouts:** antidepressant- and cognition-relevant assay effects
- **Design principle:** minimal structural edit → "nonhallucinogenic psychoplastogen" class
- **Mechanism:** promotes cortical spinogenesis / dendritic growth (same pathway as LSD)
- **Selectivity:** improved receptor pharmacology; does *not* amplify psychosis-associated behavioral or gene-expression signatures
- **Behavioral readouts:** antidepressant- and cognition-relevant assay effects
- **Design principle:** minimal structural edit → "nonhallucinogenic psychoplastogen" class
A new scientific review maps the cellular and molecular mechanisms behind memory formation, consolidation, generalization, and updating, revealing how memories are stored, altered, and even manipulated in the brain. Key breakthroughs allow scientists to visualize and activate specific neurons involved in memory, offering deeper insight into how learning occurs and how fear memories may become overgeneralized in disorders like PTSD.
