The article reviews the use of borneol, a natural compound from traditional Chinese medicine, to improve the delivery of drugs to the central nervous system by enhancing the permeability of the blood-brain barrier. It discusses the chemical properties, sources, toxicity, kinetics, and mechanisms by which borneol facilitates drug passage across the BBB.
Intranasal drug delivery can avoid gastrointestinal destruction and hepatic first-pass metabolism, resulting in rapid onset of effect and high brain bioavailability.
Intranasal drug delivery can avoid gastrointestinal destruction and hepatic first-pass metabolism, resulting in rapid onset of effect and high brain bioavailability.
A study found that exposing older adults to various odorants at night using an odorant diffuser improved their memory and increased activity in the uncinate fasciculus.
