Researchers have developed the first three-dimensional, single-cell transcriptomic atlas of a lamprey brain to uncover the evolutionary origins of vertebrate intelligence. By mapping every individual cell's spatial location and genetic activity, scientists discovered that lampreys share strikingly conserved gene-expression patterns with mammals in core brain regions, indicating that their common ancestor possessed a highly complex, molecularly organized brain over 450 million years ago.
* The identification of moonlighting neurons (AENs) that can simultaneously transmit both excitatory and inhibitory signals.
* Evidence that primitive cerebellum-like regions existed long before the evolution of jaws.
* A comparison between versatile ancestral cells and highly specialized mammalian neurons resulting from ancient genome duplications.
* The identification of moonlighting neurons (AENs) that can simultaneously transmit both excitatory and inhibitory signals.
* Evidence that primitive cerebellum-like regions existed long before the evolution of jaws.
* A comparison between versatile ancestral cells and highly specialized mammalian neurons resulting from ancient genome duplications.
