This review describes the multimodal and multinodal organization of the LPA signaling network, detailing upstream biosynthesis, receptor diversity, and downstream effectors across diverse organ systems. Therapeutic strategies targeting ATX, LPARs, and intracellular mediators are critically assessed, along with a review of ongoing and emerging clinical trials.
A new study links alcohol consumption, particularly beer and liquor, to an increased risk of pancreatic cancer. The risk increases with greater alcohol intake, even with moderate drinking (around one drink a day for women or two for men).
