Allison Parshall writes that psilocybin creates a hidden order amid brain chaos, potentially underlying the psychedelic sense of oneness, with sensory networks less connected to the brain and higher-level networks more integrated.
In a Nature study of 62 healthy adults scanned at rest, meditating, listening to music and watching a movie after dosing, participants reporting strong embeddedness showed more similar brain activity patterns across tasks than those with weaker effects.
The findings suggest the brain actively maintains the self-world boundary that psychedelics temporarily reduce, offering a neurobiological basis for context-dependent experiences.